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metronidazole will enhance the amount or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.elvitegravir/cobicistat/emtricitabine/tenofovir DF raises levels of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.This is simply not a complete list of attainable Uncomfortable side eff